In recent times, quinolone antibiotics (QNs), which simply bioaccumulate in aquatic organisms, have been broadly detected in lake ecosystems, and the bioaccumulation and trophic switch habits are clearly spatiotemporally completely different. On this research, the bioaccumulation and trophic switch habits of fourteen QNs in 9 dominant fish species had been studied, the correlation with environmental components was analyzed, and the well being threat of QNs was evaluated in Baiyangdian Lake. The outcomes confirmed that the mass concentrations of ∑QNs in water diversified from 0.7400 to 1590 ng·L. Moreover, the detected frequencies of flumequine (FLU), oxolinic acid (OXO), and ofloxacin (OFL) had been increased, and the typical mass focus of FLU was the best. The content material of ∑QNs in fish ranged from 17.1 to 146 ng·g, and the typical contents of ciprofloxacin (CIP) and OFL had been increased. The bioaccumulation components (BAF) had been within the vary of 96.2 (BAF)-489 (BAF) L·kg, indicating the bioaccumulation of QNs was low in dominant fish species. The trophic magnification components (TMF) of 5 QNs (enrofloxacin (ENR), FLU, marbofloxacin (MAR), norfloxacin (NOR), and OFL) diversified from 0.714 (TMF) to 1.33 (TMF), indicating ENR exhibited trophic magnification, whereas FLU, MAR, and ∑QNs exhibited trophic dilution. The outcomes of correlation evaluation between environmental parameters and BAF/TMF confirmed that pH, , SD, DO, COD, TP, TN, NH-N, NO-N, and PO-P had been considerably associated to the bioaccumulation of QNs in fish. The outcomes of human well being threat confirmed that the hazard quotient (HQ) of CIP (0.0040-0.026) was considerably increased than that of different QNs (≤ 0.0050), and the hazard indices (HI) ranged from 0.0010 to 0.035, indicating a excessive degree of well being threat. Due to this fact, to scale back the well being threat, the usual and residue limits of QNs ought to be set in Baiyangdian Lake.
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